December 27, 2019

Geoff MacKay
President and Chief Executive Officer
AVROBIO, Inc.
One Kendall Square
Building 300, Suite 201
Cambridge, MA 02139

       Re: AVROBIO, Inc.
           Registration Statement on Form S-3
           Filed December 20, 2019
           File No. 333-235641

Dear Mr. MacKay:

       We have limited our review of your registration statement to those
issues we have
addressed in our comment.

       Please respond to this letter by amending your registration statement
and providing the
requested information. If you do not believe our comment applies to your facts
and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

       After reviewing the information you provide in response to this comment,
we may have
additional comments.

Registration Statement on Form S-3 filed December 20, 2019

Description of Capital Stock
Choice of Forum, page 13

1.     We note your disclosure on page 13 that your forum selection provision
in your amended
       and restated bylaws identifies the Court of Chancery of the State of
Delaware as the
       exclusive forum "for any state law claim" for certain litigation,
including any "derivative
       action." However, we note that your forum selection bylaw does not
include a state law
       claim limitation. Please advise, or expand your disclosure to, if true,
explicitly state that
       this provision does not apply to actions arising under the Exchange Act.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.
 Geoff MacKay
AVROBIO, Inc.
December 27, 2019
Page 2

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Irene Paik at 202-551-6553 or Mary Beth Breslin at
202-551-3625 with
any questions.



                                                           Sincerely,
FirstName LastNameGeoff MacKay
                                                           Division of
Corporation Finance
Comapany NameAVROBIO, Inc.
                                                           Office of Life
Sciences
December 27, 2019 Page 2
cc:       James H. Xu - Goodwin Procter LLP
FirstName LastName