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<div id="toc54807_47" style="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold;text-align:center">Pay Versus Performance </div> <div style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The disclosure included in this section is prescribed by SEC rules and does not necessarily align with how the Company or the Compensation Committee view the link between the Company’s performance and Named Executive Officer pay. </div> <div style="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold"><div style="font-style: normal; letter-spacing: 0px; top: 0px;display:inline;"><div style="font-style:italic;display:inline;">Required Tabular Disclosure of Pay Versus Performance </div></div></div> <div style="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The amounts set forth below under the headings “Compensation Actually Paid to PEO” and “Average Compensation Actually Paid for Named Executive Officers” have been calculated in a manner consistent with Item 402(v) of Regulation <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">S-K.</div> </div> <div style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Use of the term “compensation actually paid” (“CAP”) is required by the SEC’s rules and as a result of the calculation methodology required by the SEC, such amounts differ from compensation actually received by the individuals. </div> <div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
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<td style="width:21%"></td>
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<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="vertical-align: bottom; white-space: nowrap; padding-bottom: 0.5pt;"><div style="margin-top: 0pt; margin-bottom: 0pt; border-bottom: 1pt solid rgb(0, 0, 0); display: table-cell; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; line-height: normal;">Year</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Summary<br/> Compensation<br/> Table Total<br/> for First<br/> PEO<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(1)(2)</div><br/> ($)</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Summary<br/> Compensation<br/> Table Total<br/> for Second<br/> PEO<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(1)(2)</div></div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Compensation<br/> Actually Paid<br/> to First<br/> PEO<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(1)(3)</div><br/> ($)</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Compensation<br/> Actually Paid<br/> to Second<br/> PEO<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(1)(3)</div></div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Average<br/> Summary<br/> Compensation<br/> Table Total<br/> for<br/> <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Non-PEO</div><br/> Named<br/> Executive<br/> Officers<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(1)(2)</div><br/> ($)</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Average<br/> Compensation<br/> Actually Paid<br/> to<br/> <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Non-PEO</div><br/> Named<br/> Executive<br/> Officers<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(1)(3)</div><br/> ($)</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Value of<br/> Initial<br/> Fixed $100<br/> Investment:<br/> Total<br/> Shareholder<br/> Return<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(4)</div><br/> ($)</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">Net<br/> Income<br/> (millions)<div style="font-size:75%; vertical-align:top;display:inline;font-size:6.6px">(5)</div></div></div><br/> <div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">($)</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:center">n/a</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">7,351,578</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:center">n/a</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">4,409,638</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">3,085,372</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">1,128,512</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">243.84</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">74,151</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">1,093,258</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:center">$5,900,979</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">956,456</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:center">$16,248,199</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">2,062,450</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">5,785,002</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">539.70</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">57,982</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2023</div></td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">1,590,892</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:center">n/a</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">1,905,484</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:center">n/a</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">1,111,951</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">1,405,801</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">190.77</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">42,823</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td></tr></table> <div style="line-height:8.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000;width:11%"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(1)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The following individuals are our PEO and other <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">non-PEO</div> Named Executive Officers for each fiscal year: </div></td></tr></table> <div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:26%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td style="width:24%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td style="width:24%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td style="width:23%"></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="vertical-align: bottom; white-space: nowrap; text-align: center; padding-bottom: 0.5pt;"><div style="margin-top: 0pt; margin-bottom: 0pt; border-bottom: 1pt solid rgb(0, 0, 0); display: inline-block; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; text-align: center; line-height: normal;">Year</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="margin-top: 0pt; margin-bottom: 1pt; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; text-align: center; line-height: normal;">First PEO</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="margin-top: 0pt; margin-bottom: 1pt; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; text-align: center; line-height: normal;">Second PEO</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="margin-top: 0pt; margin-bottom: 1pt; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; text-align: center; line-height: normal;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Non-PEO</div><br/> Named Executive<br/> Officers</div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top;text-align:right">— </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Alise Reicin, M.D.</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Daniel Lochner and Marcella K. Ruddy, M.D.</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Erik Ostrowski (through June 20, 2024)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Alise Reicin, M.D. (starting June 20, 2024)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Daniel Lochner and Marcella K. Ruddy, M.D.</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2023</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Erik Ostrowski</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top;text-align:right">— </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Geoff MacKay, Azadeh Golipour, Ph.D. and Essra Ridha, M.D., MRCP, FFPM</td></tr></table> <div style="line-height:8.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000;width:11%"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(2)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">Represents the amount of total compensation reported for our Principal Executive Officers (“PEO”) and the average total compensation for our <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">non-PEO</div> Named Executive Officers for each corresponding year in the </div></td></tr></table> <div style="margin-top:0pt;margin-bottom:0pt ; font-size:8pt"> </div> <div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:center"> </div>
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<td style="vertical-align:top;text-align:left">“Total” column of the Summary Compensation Table. Refer to “Executive Compensation—Summary Compensation Table.” </td></tr></table>
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<td style="width:4%;vertical-align:top;text-align:left">(3)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">Represents the amount of CAP to our PEOs and the average amount of CAP to our <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Non-PEO</div> Named Executive Officers, respectively, as computed in accordance with Item 402(v) of Regulation <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">S-K.</div> The dollar amounts do not reflect the actual amount of compensation earned by or paid to our Named Executive Officers during the applicable year. In accordance with the requirements of Item 402(v) of Regulation <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">S-K,</div> the following adjustments were made to the reported total compensation for each year to determine the CAP: </div></td></tr></table> <div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
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<td style="vertical-align: bottom; white-space: nowrap; text-align: center; padding-bottom: 0.5pt;"><div style="margin-top: 0pt; margin-bottom: 1pt; border-bottom: 1pt solid rgb(0, 0, 0); display: inline-block; font-size: 7pt; font-family: "Times New Roman"; text-align: center; line-height: normal;">Year</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Named<br/> Executive<br/> Officers</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Summary<br/> Compensation<br/> Table<br/> (“SCT”)<br/> Total<br/> Compensation</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Deduct: Grant<br/> Date Fair<br/> Value of the<br/> “Stock<br/> Awards” and<br/> “Option<br/> Awards”<br/> Columns in<br/> the SCT for<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add: Fair<br/> Value at<br/> Applicable<br/> FY<br/> End of<br/> Awards<br/> Granted<br/> during<br/> Applicable<br/> FY<br/> that Remain<br/> Unvested as<br/> of<br/> Applicable<br/> FY<br/> End*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add: Change<br/> in Fair Value<br/> from the end<br/> of the Prior<br/> FY to the end<br/> of the<br/> Applicable<br/> FY<br/> of Awards<br/> Granted<br/> during Prior<br/> FY that were<br/> Outstanding<br/> and Unvested<br/> as of<br/> Applicable<br/> FY<br/> End*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add:<br/> Vesting<br/> Date Fair<br/> Value of<br/> Awards<br/> Granted<br/> during<br/> Applicable<br/> FY that<br/> Vested<br/> During<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add: Change<br/> in<br/> Fair Value<br/> from<br/> the end of<br/> Prior<br/> FY to<br/> Vesting<br/> Date Fair<br/> Value of<br/> Awards<br/> Granted<br/> during Prior<br/> FY<br/> that Vested<br/> During<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Deduct:<br/> Fair<br/> Value at<br/> Prior<br/> Year End<br/> of<br/> Awards<br/> Granted<br/> during<br/> Prior FY<br/> that were<br/> Forfeited<br/> during<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">CAP</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8.5pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 8.5pt; font-family: "Times New Roman"; line-height: normal;">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">Second<br/> PEO</td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">7,351,578</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">6,320,470</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">2,840,810</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">5,326,514</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">366,400</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">3,321,442</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right"> — </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">($</div></div></td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">4,409,638</div></div></td>
<td style="white-space:nowrap;vertical-align:bottom"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">) </div></div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8.5pt;background-color:#cceeff">
<td style="vertical-align:top"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">Average<br/> <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Non-PEO</div><br/> Named<br/> Executive<br/> Officers</td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">3,085,372</td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">($</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">2,359,391</td>
<td style="white-space:nowrap;vertical-align:top">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">1,079,391</td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">($</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">1,892,181</td>
<td style="white-space:nowrap;vertical-align:top">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">118,761</td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">($</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">1,160,464</td>
<td style="white-space:nowrap;vertical-align:top">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">— </td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">($</div></div></td>
<td style="white-space:nowrap;vertical-align:top;text-align:right"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">1,128,512</div></div></td>
<td style="white-space:nowrap;vertical-align:top"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">) </div></div></td></tr></table> <div style="line-height:8.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000;width:11%"> </div>
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<td style="width:4%;vertical-align:top;text-align:left">*</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant. </div></td></tr></table>
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<td style="width:4%;vertical-align:top;text-align:left">(4)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">For the relevant fiscal year, represents the cumulative Total Shareholder Return (“TSR”) of our common stock at the end of each fiscal year, assuming an initial investment of $100 on December 31, 2022. </div></td></tr></table>
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<td style="width:4%;vertical-align:top;text-align:left">(5)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The dollar amounts reported represent the amount of net loss reflected in the Company’s audited financial statements for the applicable year. </div></td></tr></table>
7351578
-4409638
3085372
-1128512
243.84
-74151000000
1093258
5900979
956456
16248199
2062450
5785002
539.7
-57982000000
1590892
1905484
1111951
1405801
190.77
-42823000000
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<td style="width:4%;vertical-align:top;text-align:left">(1)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The following individuals are our PEO and other <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">non-PEO</div> Named Executive Officers for each fiscal year: </div></td></tr></table> <div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
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<td style="width:26%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td style="width:24%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td style="width:24%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td style="width:23%"></td></tr>
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<td style="vertical-align: bottom; white-space: nowrap; text-align: center; padding-bottom: 0.5pt;"><div style="margin-top: 0pt; margin-bottom: 0pt; border-bottom: 1pt solid rgb(0, 0, 0); display: inline-block; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; text-align: center; line-height: normal;">Year</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="margin-top: 0pt; margin-bottom: 1pt; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; text-align: center; line-height: normal;">First PEO</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="margin-top: 0pt; margin-bottom: 1pt; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; text-align: center; line-height: normal;">Second PEO</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="margin-top: 0pt; margin-bottom: 1pt; font-size: 8pt; font-family: "Times New Roman"; font-weight: bold; text-align: center; line-height: normal;"><div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Non-PEO</div><br/> Named Executive<br/> Officers</div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top;text-align:right">— </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Alise Reicin, M.D.</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Daniel Lochner and Marcella K. Ruddy, M.D.</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2024</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Erik Ostrowski (through June 20, 2024)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Alise Reicin, M.D. (starting June 20, 2024)</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Daniel Lochner and Marcella K. Ruddy, M.D.</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 10pt; font-family: "Times New Roman"; line-height: normal;">2023</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Erik Ostrowski</td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top;text-align:right">— </td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:top">Geoff MacKay, Azadeh Golipour, Ph.D. and Essra Ridha, M.D., MRCP, FFPM</td></tr></table>
Alise Reicin
Erik Ostrowski
Alise Reicin
Erik Ostrowski
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<td style="width:4%;vertical-align:top;text-align:left">(3)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">Represents the amount of CAP to our PEOs and the average amount of CAP to our <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Non-PEO</div> Named Executive Officers, respectively, as computed in accordance with Item 402(v) of Regulation <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">S-K.</div> The dollar amounts do not reflect the actual amount of compensation earned by or paid to our Named Executive Officers during the applicable year. In accordance with the requirements of Item 402(v) of Regulation <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">S-K,</div> the following adjustments were made to the reported total compensation for each year to determine the CAP: </div></td></tr></table> <div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8.5pt;width:100%;border-spacing:0;margin:0 auto">
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<td style="width:31%"></td>
<td style="vertical-align:bottom;width:1%"></td>
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<td style="vertical-align:bottom;width:1%"></td>
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<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
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<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
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<td style="vertical-align:bottom;width:1%"></td>
<td></td>
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<td></td>
<td style="vertical-align:bottom;width:1%"></td>
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<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td></td>
<td></td></tr>
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<td style="vertical-align: bottom; white-space: nowrap; text-align: center; padding-bottom: 0.5pt;"><div style="margin-top: 0pt; margin-bottom: 1pt; border-bottom: 1pt solid rgb(0, 0, 0); display: inline-block; font-size: 7pt; font-family: "Times New Roman"; text-align: center; line-height: normal;">Year</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Named<br/> Executive<br/> Officers</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Summary<br/> Compensation<br/> Table<br/> (“SCT”)<br/> Total<br/> Compensation</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Deduct: Grant<br/> Date Fair<br/> Value of the<br/> “Stock<br/> Awards” and<br/> “Option<br/> Awards”<br/> Columns in<br/> the SCT for<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add: Fair<br/> Value at<br/> Applicable<br/> FY<br/> End of<br/> Awards<br/> Granted<br/> during<br/> Applicable<br/> FY<br/> that Remain<br/> Unvested as<br/> of<br/> Applicable<br/> FY<br/> End*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add: Change<br/> in Fair Value<br/> from the end<br/> of the Prior<br/> FY to the end<br/> of the<br/> Applicable<br/> FY<br/> of Awards<br/> Granted<br/> during Prior<br/> FY that were<br/> Outstanding<br/> and Unvested<br/> as of<br/> Applicable<br/> FY<br/> End*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add:<br/> Vesting<br/> Date Fair<br/> Value of<br/> Awards<br/> Granted<br/> during<br/> Applicable<br/> FY that<br/> Vested<br/> During<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add: Change<br/> in<br/> Fair Value<br/> from<br/> the end of<br/> Prior<br/> FY to<br/> Vesting<br/> Date Fair<br/> Value of<br/> Awards<br/> Granted<br/> during Prior<br/> FY<br/> that Vested<br/> During<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Deduct:<br/> Fair<br/> Value at<br/> Prior<br/> Year End<br/> of<br/> Awards<br/> Granted<br/> during<br/> Prior FY<br/> that were<br/> Forfeited<br/> during<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">CAP</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8.5pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 8.5pt; font-family: "Times New Roman"; line-height: normal;">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">Second<br/> PEO</td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">7,351,578</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">6,320,470</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">2,840,810</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">5,326,514</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">366,400</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">3,321,442</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right"> — </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">($</div></div></td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">4,409,638</div></div></td>
<td style="white-space:nowrap;vertical-align:bottom"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">) </div></div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8.5pt;background-color:#cceeff">
<td style="vertical-align:top"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">Average<br/> <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Non-PEO</div><br/> Named<br/> Executive<br/> Officers</td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">3,085,372</td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">($</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">2,359,391</td>
<td style="white-space:nowrap;vertical-align:top">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">1,079,391</td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">($</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">1,892,181</td>
<td style="white-space:nowrap;vertical-align:top">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">118,761</td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">($</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">1,160,464</td>
<td style="white-space:nowrap;vertical-align:top">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">— </td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">($</div></div></td>
<td style="white-space:nowrap;vertical-align:top;text-align:right"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">1,128,512</div></div></td>
<td style="white-space:nowrap;vertical-align:top"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">) </div></div></td></tr></table> <div style="line-height:8.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000;width:11%"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">*</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant. </div></td></tr></table>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">(3)</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">Represents the amount of CAP to our PEOs and the average amount of CAP to our <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Non-PEO</div> Named Executive Officers, respectively, as computed in accordance with Item 402(v) of Regulation <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">S-K.</div> The dollar amounts do not reflect the actual amount of compensation earned by or paid to our Named Executive Officers during the applicable year. In accordance with the requirements of Item 402(v) of Regulation <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">S-K,</div> the following adjustments were made to the reported total compensation for each year to determine the CAP: </div></td></tr></table> <div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8.5pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:31%"></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td></td>
<td></td>
<td style="vertical-align:bottom;width:1%"></td>
<td></td>
<td></td>
<td></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:7pt">
<td style="vertical-align: bottom; white-space: nowrap; text-align: center; padding-bottom: 0.5pt;"><div style="margin-top: 0pt; margin-bottom: 1pt; border-bottom: 1pt solid rgb(0, 0, 0); display: inline-block; font-size: 7pt; font-family: "Times New Roman"; text-align: center; line-height: normal;">Year</div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Named<br/> Executive<br/> Officers</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Summary<br/> Compensation<br/> Table<br/> (“SCT”)<br/> Total<br/> Compensation</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Deduct: Grant<br/> Date Fair<br/> Value of the<br/> “Stock<br/> Awards” and<br/> “Option<br/> Awards”<br/> Columns in<br/> the SCT for<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add: Fair<br/> Value at<br/> Applicable<br/> FY<br/> End of<br/> Awards<br/> Granted<br/> during<br/> Applicable<br/> FY<br/> that Remain<br/> Unvested as<br/> of<br/> Applicable<br/> FY<br/> End*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add: Change<br/> in Fair Value<br/> from the end<br/> of the Prior<br/> FY to the end<br/> of the<br/> Applicable<br/> FY<br/> of Awards<br/> Granted<br/> during Prior<br/> FY that were<br/> Outstanding<br/> and Unvested<br/> as of<br/> Applicable<br/> FY<br/> End*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add:<br/> Vesting<br/> Date Fair<br/> Value of<br/> Awards<br/> Granted<br/> during<br/> Applicable<br/> FY that<br/> Vested<br/> During<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Add: Change<br/> in<br/> Fair Value<br/> from<br/> the end of<br/> Prior<br/> FY to<br/> Vesting<br/> Date Fair<br/> Value of<br/> Awards<br/> Granted<br/> during Prior<br/> FY<br/> that Vested<br/> During<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center">Deduct:<br/> Fair<br/> Value at<br/> Prior<br/> Year End<br/> of<br/> Awards<br/> Granted<br/> during<br/> Prior FY<br/> that were<br/> Forfeited<br/> during<br/> Applicable<br/> FY*</td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td>
<td colspan="2" style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">CAP</div></div></td>
<td style="vertical-align: bottom; padding-bottom: 0.5pt;"> </td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8.5pt;background-color:#cceeff">
<td style="vertical-align:top"><div style="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font-size: 8.5pt; font-family: "Times New Roman"; line-height: normal;">2025</div></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">Second<br/> PEO</td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">7,351,578</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">6,320,470</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">2,840,810</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">5,326,514</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">366,400</td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">($</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right">3,321,442</td>
<td style="white-space:nowrap;vertical-align:bottom">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom">$</td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right"> — </td>
<td style="white-space:nowrap;vertical-align:bottom"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:bottom"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">($</div></div></td>
<td style="white-space:nowrap;vertical-align:bottom;text-align:right"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">4,409,638</div></div></td>
<td style="white-space:nowrap;vertical-align:bottom"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">) </div></div></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8.5pt;background-color:#cceeff">
<td style="vertical-align:top"></td>
<td style="vertical-align:bottom"> </td>
<td style="vertical-align:bottom;white-space:nowrap">Average<br/> <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Non-PEO</div><br/> Named<br/> Executive<br/> Officers</td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">3,085,372</td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">($</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">2,359,391</td>
<td style="white-space:nowrap;vertical-align:top">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">1,079,391</td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">($</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">1,892,181</td>
<td style="white-space:nowrap;vertical-align:top">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">118,761</td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">($</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">1,160,464</td>
<td style="white-space:nowrap;vertical-align:top">) </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top">$</td>
<td style="white-space:nowrap;vertical-align:top;text-align:right">— </td>
<td style="white-space:nowrap;vertical-align:top"> </td>
<td style="vertical-align:bottom"> </td>
<td style="white-space:nowrap;vertical-align:top"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">($</div></div></td>
<td style="white-space:nowrap;vertical-align:top;text-align:right"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">1,128,512</div></div></td>
<td style="white-space:nowrap;vertical-align:top"><div style="letter-spacing: 0px; top: 0px;display:inline;"><div style="font-weight:bolder;display:inline;">) </div></div></td></tr></table> <div style="line-height:8.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000;width:11%"> </div>
<table cellpadding="0" cellspacing="0" style="text-align:start; BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left">*</td>
<td style="vertical-align:top;text-align:left"><div style="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; font-family: "Times New Roman"; text-align: left; line-height: normal;">The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant. </div></td></tr></table>
7351578
-6320470
2840810
-5326514
366400
-3321442
0
-4409638
3085372
-2359391
1079391
-1892181
118761
-1160464
0
-1128512
The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant.
<div style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><div style="font-style: normal; letter-spacing: 0px; top: 0px;display:inline;"><div style="font-style:italic;display:inline;">CAP and Net Loss </div></div></div> <div style="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The chart below shows the relationship between the compensation actually paid to our PEOs and the average compensation actually paid to our <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">non-PEO</div> Named Executive Officers, on the one hand, to the Company’s Net Loss over the three years presented in the table, on the other. </div> <div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div> <div style="margin-top:0pt;margin-bottom:0pt;text-align:center">
<img alt="" src="g54807g11a01.jpg" style="width: 556.533px;height: 275.11px;"/><br/></div>
<div style="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><div style="font-style: normal; letter-spacing: 0px; top: 0px;display:inline;"><div style="font-style:italic;display:inline;">CAP and Cumulative TSR </div></div></div> <div style="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The chart below shows the relationship between the CAP to our PEOs and the average CAP to our <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">non-PEO</div> Named Executive Officers, on the one hand, to the Company’s cumulative TSR over the three years presented in the table, on the other. </div> <div style="font-size:12pt;margin-top:0pt;margin-bottom:0pt"> </div> <div style="margin-top:0pt;margin-bottom:0pt;text-align:center">
<img alt="" src="g54807g11b02.jpg" style="width: 567.999px;height: 268.587px;"/><br/></div>
<div id="toc54807_48" style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold;text-align:center">Policies and Practices Related to the Grant of Certain Equity Awards Close in Time to the Release of Material Nonpublic Information </div> <div style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">From time to time, the Company grants stock options to its employees, including the Named Executive Officers. Beginning in fiscal year 2025, the Company grants annual refresh employee option grants in February and September of each year. Also, <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">non-employee</div> directors receive automatic grants of initial and annual stock option awards, at the time of a director’s initial appointment or election to the board and at the time of each annual meeting of the Company’s stockholders, respectively, pursuant to the <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Non-Employee</div> Director Compensation Policy, as further described under the heading, <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">“Non-Employee</div> Director <div style="white-space: nowrap; letter-spacing: 0px; top: 0px;display:inline;">Compensation—Non-Employee</div> Director Compensation Policy” below. The Company does not otherwise maintain any written policies on the timing of awards of stock options, stock appreciation rights, or similar instruments with option-like features. The Compensation Committee considers whether there is any material nonpublic information (“MNPI”) about the Company when determining the timing of stock option grants and does not seek to time the award of stock options in relation to the Company’s public disclosure of MNPI. The Company has not timed the release of MNPI for the purpose of affecting the value of executive compensation. </div>
true
true
The Compensation Committee considers whether there is any material nonpublic information (“MNPI”) about the Company when determining the timing of stock option grants and does not seek to time the award of stock options in relation to the Company’s public disclosure of MNPI.
false