|
|
|
(State or other jurisdiction of incorporation)
|
(Commission File Number)
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(I.R.S. Employer Identification No.)
|
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
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Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
|
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
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Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
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Title of each class
|
Trading
symbol(s)
|
Name of each exchange
on which registered
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||
|
|
|
Item 2.02 |
Results of Operations and Financial Condition.
|
Item 9.01 |
Financial Statements and Exhibits.
|
Press release issued by AVROBIO, Inc., dated August 9, 2022.
|
|
104
|
The cover page from this Current Report on Form 8-K, formatted in Inline XBRL.
|
AVROBIO, INC.
|
||
Date: August 9, 2022
|
By:
|
/s/ Geoff MacKay
|
Geoff MacKay
|
||
President and Chief Executive Officer
|
• |
Early data indicate that post HSC gene therapy, patients have been able to produce functional cystinosin protein throughout the body, as evidenced by measurements of blood, eye, skin and gastrointestinal mucosa, which indicate a reduction
in the accumulation of cystine crystals or prevention of further pathological accumulation
|
• |
Sustained engraftment demonstrated by stable vector copy number (VCN) in patients beyond 12 months with all five dosed patients remaining off oral cysteamine post gene therapy
|
• |
Data from the five patients dosed to date indicate no adverse events (AEs) related to drug product. All AEs were related to myeloablative conditioning, stem cell mobilization, underlying disease or pre-existing conditions
|
• |
Collaborator-sponsored Phase 1/2 clinical trial is funded in part by grants to University of California San Diego from the California Institute for Regenerative Medicine (CIRM), Cystinosis
Research Foundation (CRF) and National Institutes of Health (NIH)
|
• |
Read full press release here
|
• |
Read full press release here
|
• |
Eight months post infusion, substrate levels were reduced across multiple tissues to levels nearly indistinguishable from healthy mice
|
• |
Read full press release here
|
• |
AVR-RD-04 in cystinosis: Plan to engage with regulatory agencies in 2H 2022 to discuss our clinical development and regulatory strategy with the intent of initiating a company-sponsored clinical trial in 2023, subject
to regulatory alignment
|
• |
AVR-RD-02 in Gaucher disease:
|
o |
Gaucher disease type 1: Plan to provide interim clinical data update in 2H 2022
|
o |
Gaucher disease type 3: Plan to engage with regulatory agencies on a Phase 2/3 clinical development strategy with aim to initiate a trial in 2023, subject to regulatory alignment
|
• |
AVR-RD-05 in Hunter syndrome: Clinical Trial Application (CTA) authorization expected 2H 2022 with plans to initiate a collaborator-sponsored Phase 1/2 clinical trial in 2023, subject to regulatory alignment
|
June 30,
|
December 31,
|
|||||||
2022
|
2021
|
|||||||
Cash and cash equivalents
|
$
|
132,409
|
$
|
189,567
|
||||
Prepaid expenses and other current assets
|
9,672
|
9,578
|
||||||
Property and equipment, net
|
3,618
|
4,126
|
||||||
Other assets
|
545
|
566
|
||||||
Total assets
|
$
|
146,244
|
$
|
203,837
|
||||
Accounts payable
|
$
|
28
|
$
|
3,486
|
||||
Accrued expenses and other current liabilities
|
12,757
|
15,900
|
||||||
Note payable, net of discount
|
15,104
|
14,945
|
||||||
Deferred rent, net of current portion
|
12
|
30
|
||||||
Total liabilities
|
$
|
27,901
|
$
|
34,361
|
||||
Total stockholders’ equity
|
118,343
|
169,476
|
||||||
Total liabilities and stockholders’ equity
|
$
|
146,244
|
$
|
203,837
|
Three Months Ended June 30,
|
Six Months Ended June 30,
|
|||||||||||||||
2022
|
2021
|
2022
|
2021
|
|||||||||||||
Operating expenses:
|
||||||||||||||||
Research and development
|
$
|
18,877
|
$
|
22,544
|
$
|
38,130
|
$
|
41,024
|
||||||||
General and administrative
|
8,897
|
8,831
|
19,062
|
17,235
|
||||||||||||
Total operating expenses
|
27,774
|
31,375
|
57,192
|
58,259
|
||||||||||||
Loss from operations
|
(27,774
|
)
|
(31,375
|
)
|
(57,192
|
)
|
(58,259
|
)
|
||||||||
Other (expense) income, net
|
(280
|
)
|
(12
|
)
|
(695
|
)
|
(27
|
)
|
||||||||
Net loss
|
$
|
(28,054
|
)
|
$
|
(31,387
|
)
|
$
|
(57,887
|
)
|
$
|
(58,286
|
)
|
||||
Net loss per share — basic and diluted
|
$
|
(0.64
|
)
|
$
|
(0.74
|
)
|
$
|
(1.32
|
)
|
$
|
(1.39
|
)
|
||||
Weighted-average number of common shares outstanding — basic and diluted
|
43,696
|
42,510
|
43,696
|
42,067
|